Happy Birthday to Both of You Harvey Dent

first_imgToday we celebrate the life and times of a young gun District Attorney who tried his best to clean up the streets of Gotham.  Conjured by  Bill Finger and Bob Kane in 1942 for Detective Comics, Harvey’s good looks, kind heart, and ambitions won us over.But tragedy befalls our noble hero as he is driven insane. Driven insane, when half of himself is melted with acid; thus beginning the reign of Two-Face. Not only is he one of DC Comics’ best villains but he’s one of graphic novels best across the board. Our pals at IGN even voted him #12 on their Top 100 Comic Book Villains of All Time! That’s some serious clout.He’s also been brought to life by some pretty great actors as well: Billy Dee Willaims, Tommy Lee Jones, Aaron Eckhart, Richard Moll, and Troy Baker.So whether you voted for Dent or cheer for Two-Face…you can’t have one without the other. Happy Birthday, Harv and thanks for the memories.Here are 20 stunning pieces of art featuring one of Gotham’s most devious inhabitants.Via Rafa ToroView as: One Page Slides1. Dave Bardin2. Ivan Camelo3. Godmachine4. Maxime Cottin5. Aaron Lopresti6. Huang Danlan7. Kiwi Sherman8. Rich D9. Nico Art10. Ai Eye11. Zach Brown12. Zach Brown13. Chris Samnee14. Nychos15. M. Lang16. Brett Weldele17. Gingashi18. Dan Mora19. Jinhoan Kim20. Amir Moshinlast_img read more

Scientists find key link between viruses and inflammatory bowel diseases

first_img Source:http://www.ucdenver.edu/ Jul 23 2018A study led by a researcher at the University of Colorado Anschutz Medical Campus reveals a key connection between viruses and inflammatory bowel diseases like ulcerative colitis and Crohn’s disease.Breck Duerkop, PhD, assistant professor of immunology and microbiology at the University of Colorado School of Medicine, and a team of scientists focused on viruses inhabiting bacteria in the intestine known as bacteriophages or simply phages.”Phage numbers are elevated at the intestinal mucosal surface and increase in abundance during inflammatory bowel disease (IBD), suggesting that phages play an unidentified role in IBD,” said Duerkop, lead author of the study published Monday in the journal Nature Microbiology.Related StoriesGene modulation goes wireless hacking the “boss gene”Getting rid of chronic infections by waking up sleeping bacteriaStudy shows link between gut microbiome health and successful joint replacementIBD poses significant health burdens worldwide and has inspired intense investigation into the environmental factors causing persistent inflammation of the intestine. Microbial communities are critical in maintaining intestinal health but changes in the composition of these organisms may cause an inflammatory response by the body.According to Duerkop, most studies looking at how these microbial communities might spark inflammation have focused chiefly on bacteria rather than the viruses residing inside them.When inflammation occurs, Duerkop found that phage communities change randomly leading to a genetic signature indicative of the inflammatory environment.”We hypothesize that inflammation or other host defenses alter phage abundances during colitis,” the study said. “Such stresses could produce ecological disturbances in the intestinal environment, driving alterations within the viral community.”Those disturbances could be the result of the viruses killing off beneficial bacteria in the intestine and allowing for `bad actor’ bacteria to cause inflammation and bowel disease.The experiments were done with mice.”What we see in mice is consistent with what we see in humans with IBD,” Duerkop said.While the mechanics of how these phages operate will require further study, Duerkop said this discovery could lead to new kinds of treatment for these often debilitating diseases.Clinicians could target certain bacteria with viruses to eliminate bacteria that lead to inflammation. Bacteria could be manipulated to circumvent the development of disease.”We could promote the growth of good bacteria – a kind of phage therapy,” Duerkop said. “We could perhaps use phages as markers to identify someone predisposed to developing these diseases. While there is clearly more research to do, the potential is very exciting.”last_img