Share your voice Now playing: Watch this: Netflix may have finally broken into the last area of Hollywood it has yet to conquer: the Oscars. On Sunday, Netflix won multiple Oscars as the awards ceremony stretched on, with Alfonso Cuarón winning for Roma’s directing and its cinematography, and Roma itself winning for foreign language film. Netflix’s Period. End of Sentence also won in the documentary short category. But Roma fell short of the ultimate prize, a best picture Oscar. Of Netflix’s 15 nominations, other contenders bested the streaming giant in different categories, including Roma’s nominations for leading actress, supporting actress, production design, sound editing, sound mixing and original screenplay, as well as The Ballad of Buster Scruggs’ nominations for costume design, original song and adapted screenplay. Netflix had a second nominee, End Game, in the documentary short category that lost out to its Period. End of Sentence. Comments Tags Last year, Amazon beat Netflix to become the first streaming service to be nominated for a best picture Oscar, for Manchester by the Sea. Though the bleak film won statues for best actor and best original screenplay, it didn’t cinch the best picture title — leaving that milestone untouched for another streamer. The Oscars haven’t totally overlooked Netflix. Its documentaries have been perennial nominees. The company also won an Oscar for documentary short film in 2017 for The White Helmets, about volunteer rescue workers in bomb-ravaged Syria, and it took home a feature-film documentary Oscar last year for Icarus, about doping among competitive cyclists. And Mudbound, a period drama, racked up four nominations last year. (It won none.)But that pales in comparison to Netflix’s Emmys track record for TV programming. Netflix tied juggernaut HBO for the most Emmy wins last year, and it beat HBO in the number of nominations for the first time. First published on Feb. 24 at 5:47 p.m. PT. Updates on Feb. 24 at 6:58 p.m. PT; 7:30 p.m. PT; 8:09 p.m. PT; and 8:18 p.m. PT; and Feb. 25 at 9:18 a.m. PT: Adds results and statement from Netflix executive. 42 Photos Netflix hauled in Oscars but couldn’t quite land best… 4 Oscars 2019 Netflix 2:06 “Against all the odds, a black-and-white Spanish-language film with previously little-known talent has been embraced by the Academy across three categories including Best Foreign Film and Best Director — as it was by audiences the world over,” Ted Sarandos, Netflix’s head of content, said in a statement. He also congratulated the creators of Period for bringing attention to the “important but underreported issue” of how taboos about menstruation limit opportunities for women and girls. Even without a best picture Oscar, the victories marked a big night for Netflix. Roma, the black-and-white period piece hailed as Cuarón’s masterpiece, was nominated in 10 categories, tying with The Favourite for the most nominations this year, and it won three in high-profile categories. Netflix was relying on Roma, which won the Golden Globe for best foreign language motion picture and a Bafta for best film, to finally earn it Oscar prestige. The wins burnish Netflix’s credibility as a go-to place for top-tier original films. While Netflix is known for television-award darlings like The Crown or Master of None, the streaming service’s films have gotten the cold shoulder from the Oscars in the past. As Netflix hikes prices higher this year to offset its eye-popping spending on content, its rep as a home for prestigious films is key to keeping membership growing and drawing in top talent. TV and Movies Digital Media 40 films (and a tech company) you didn’t know won Oscarsread more
The Indian contingent.Hagen Hopkins/Getty ImagesTeam India’s jersey sponsors Chinese mobile-maker OPPO is reportedly going to part ways with the Men in Blue as Bangalore-based education technology and online tutoring firm Byju’s will take over the jerseys rights, as reported by the Times of India. The name of the Chinese mobile company which bought the jersey rights in March 2017 with a whopping winning bid of Rs 1,079 crore, will no longer feature on the Team India jersey from the month of September.As per TOI reports, OPPO decided to discontinue the deal and gave it to Byju’s because they have found the sum of money to be very high and also unsustainable.Byju’s, currently valued at Rs 38,000 crore was started in 2013 by Kerala-based entrepreneur Byju Raveendran and in the present financial year, they have ensured funding of around Rs 5,172 crore from global investors which include Chan-Zuckerberg Initiative. They have been also looking for branding excercises of such a huge volume so it fits them perfectly, sources told TOI. Team India sporting the special cap.Robert Cianflone/Getty Images”They’ve been looking for branding exercises of this volume and it’s (Team India jersey rights) is just the kind of space they wanted to get into. At the moment they fit absolutely well here,” said sources.BCCI will receive the same sum of money from Byju’s and will not incur any loss for the deal till it ends on March 31, 2022, according to a BCCI source. The South Africa tour will feature the Indian team sporting the national team jersey with Byju’s name on it and the work of changing the jersey is already on, sources mentioned.”Basically, what Oppo has done is cut its losses. They’ve reassigned the rights to Byju’s. They will pay Byju’s a minor amount to help make the full payment while Byju’s will pay BCCI. The board will continue to get what is due to it,” sources told TOI.The Men in Blue are going to face West Indies in the Caribbeans for three ODIs and T20s and two Tests. The Test series will be a part of ICC’s World Test Championship.read more
A female school teacher was killed in a road accident near Bhalaipur-Ramnagar bridge in Damurhuda upazila of Chuadanga district on Wednesday afternoon.The deceased is Hasina Begum, wife of a certain late Sujat Ali of Gopalpur village, also a teacher of Mathaldanga High School, reports UNB.Quoting local people, the police said Hasina Begum fell down from the vehicle while she was returning home after visiting a physician around 4:00pm and sustained serious injuries.She was taken to Chuadanga Sadar Hospital where on-duty physician declared her dead on arrival.
Rohingya refugees make their way to a refugee camp after crossing the Bangladesh-Myanmar border in Palong Khali, near Cox`s Bazar.File photo ReutersThe International Federation of Red Cross and Red Crescent Societies (IFRC) has warned that more than 380,000 children were at a risk of losing their future as the Rohingya crisis in southeast part of Bangladesh would be prolonged.”With an uncertain future and no solutions in sight, the world must not let these children lose their future,” said secretary general, Bangladesh Red Crescent Society M Feroz Salah Uddin.IFRC warned the situation would be more fragile in the coming monsoon and cyclone season or a disease outbreak could trigger a disaster within a disaster, said a press release.To help protect children and their families in the displaced and host communities, the Red Cross Red Crescent is prioritising contingency planning and preparedness to respond to new challenges, and building community resilience to threats including disease, cyclones and the monsoon, along with continued humanitarian assistance for 200,000 people.According to the release, the scale and speed of the displacement and the severe vulnerability of many of those displaced has created one of the most critical and complex humanitarian crises in the Asia Pacific region in decades.
Bangabandhu‘s 7 March speechThe Japanese version of the historic 7 March speech delivered by the father of the nation Bangabandhu Sheikh Mujibur Rahman at the then Race-Course Ground in 1971 has been published by the embassy of Bangladesh, Tokyo, reports UNB.The speech was translated into Japanese as the first foreign language after English.Prime minister Sheikh Hasina, while visiting Japan on 29 May, launched and unwrapped the booklet of Japanese edition of 7th March speech.The booklet will be distributed to the educational institutions and other important institutions in Japan, said the Bangladesh embassy in Tokyo on Monday.Bangabandhu’s ‘Unfinished Memoir’ and a graphic novel ‘Mujib’ were also translated into Japanese as the first foreign language after English.In November 2018, graphic novel ‘Mujib’ was launched in Tokyo by the younger daughter of Bangabandhu Sheikh Rehana and Akie Abe, the First Lady of Japan.read more
Story Links The season will highlight one of the best Cardinal recruiting classes in recent memory. The 2019 UofL volleyball recruiting class was ranked No. 16 in the nation, the highest ranked class in the ACC and the highest ranking Cardinal class since 2006. “It is very exciting to start the 2019 season,” said Busboom Kelly of her No. 25-ranked Cardinals. “We have a bunch of new players and faces. We lost four starters from last season but so far this has been an amazing preseason. This group has worked really hard on their connection with each other on and off the court. It does not feel like we are a younger, inexperienced team. So they have been a joy to coach and we can’t wait to show everyone what we have been working so hard on.” Single match tickets can be bought here The Cardinals will host Miami (Ohio) next Saturday at 3 p.m. for an exhibition match at L&N Federal Credit Union Arena as the final tuneup before the onset of the regular season. Admission is free. Tickets can also be purchased by phone at 502-GO-CARDS, or by visiting the Louisville Cardinals Ticket Office, located near Gate 2 at Cardinal Stadium (2800 South Floyd Street) on weekdays from 9 a.m., until 5 p.m., ET. Single match tickets will also be available for purchase on match days at the L&N Federal Credit Union Arena ticket windows starting one hour prior to match time. The RedHawks return five starters plus their libero to go along with 13 letterwinners from a team that went 23-9 last season and was co-MAC champions with a 13-3 record. Although the RedHawks won the MAC championship in both 2016 and 2017, they were picked to finish third in the East Division after graduating seven seniors in 2017. With a dynamic recruiting class, Miami picked up right where it left off, winning 13 out of 16 league games to share the MAC crown with Bowling Green. The RedHawks advanced to the MAC Tournament final for the fourth time in five seasons and earned their first postseason victory in 20 years when they defeated Northern Kentucky in the first round of the NIVC. To see the complete schedule, click here Print Friendly Version The Cardinals home slate includes 15 matches against teams that were nationally ranked in 2018, as well as 11 matches against teams that earned an NCAA Tournament berth last season. The Cardinals posted a 22-9 record in the 2018 season and made their 27th appearance in the NCAA Tournament. UofL is led by returning HM All-American Melanie McHenry as well as starters Emily Scott and Piper Roe, a member of the US Collegiate National Team. The ranking was announced by PrepVolleyball.com, where a panel of college coaches from across the country and representing all three NCAA women’s volleyball divisions determines the top list of classes.read more
Stay on target The news of Jason Blossom’s body being found is giving Archie nightmares. He sneaks out of the house and runs to Miss Grundy’s, trying to convince her to tell the police what they heard the night of Jason’s death. She convinces him not to. She could get fired (absolutely), Archie could get expelled (doubtful), and they both could to jail. Sorry, but no. Grundy is the criminal here. Victims don’t go to jail.Riverdale spent it’s second episode fixing the relationships that were broken in the pilot. After Betty’s mother forbids her to see Cheryl, Veronica and especially Archie, Betty knocks on Archie’s door. After a walk to school where Betty tries hard to pretend she’s OK with everything, she’s called to the office. Someone has left her flowers. That someone turns out to be Veronica, who is also trying hard to patch things up. In addition to the flowers, she ordered Betty a cupcake from New York’s Magnolia Bakery.Betty accepts the offers of friendship, but she clearly isn’t OK. As she explains to Kevin, once Veronica feels better about herself, they’ll barely say “hi” to each other in the hallway. Man, remember when these were the biggest problems you had to deal with? At lunch, she and Veronica sit with Archie and ask him to play a song he’s been working on. Hearing Archie sing brings all the emotions back up, and Betty runs off. She never even gets to eat her cupcake. (No big loss, really. Magnolia cupcakes are dry, expensive and not as good as they’re made out to be.)Camila Mendes as Veronica Lodge (Photo: Diyah Pera/The CW)That afternoon during cheerleading practice, Veronica tries to make amends by gossiping over what a monster Cheryl is being. Betty isn’t having it. She snubs Veronica by offering to hang out with Cheryl after practice. That turns out to be a terrible idea. Cheryl starts asking inappropriate questions about Betty’s sister, specifically her relationship with Jason. When Cheryl outright accuses Betty’s sister of killing Jason, Betty finally stands up for herself. She tells Cheryl to get out of her house, or she’ll kill her. Maybe not a great thing to say to someone who’s brother has just been murdered, but who cares? Cheryl had it coming.Meanwhile, Archie is dealing with his own problems. We learn exactly why he and Jughead aren’t on friendly terms anymore. They planned a road trip over Fourth of July weekend, and Archie canceled at the last minute. Dick move, Archie. Especially because, much like he is in the comics, Jughead is the smartest guy in town. It’s just that nobody listens to him. When he sees Miss Grundy cuddling up to Archie, he sees that relationship for what it is. She’s a predator, and she’s manipulating Archie. Of course, telling Archie, this only causes another fight between the two.Honestly, the most heartening thing about the second episode of Riverdale was how they treated the Archie/Grundy plot. The show doesn’t see it as a sexy, forbidden relationship. Grundy knows exactly what she’s doing. When Archie tries to convince her to talk to the police, he asks her if what they have is real. If it’s not, he says, he doesn’t know what he’s protecting. That sends Grundy into self-preservation mode, and she says, of course, it’s real. That is abusive behavior. This plot may be the most by-the-book teen drama cliche of the entire show, but at least they’re taking it seriously. That’s more than most teenage soap operas have done.Ross Butler as Reggie Mantle, Cole Sprouse as Jughead Jones and KJ Apa as Archie Andrews (Photo: Dean Buscher/The CW)The Archie-Jughead friendship slowly gets put back together, which is a relief. Their beef with each other was the weirdest, most out-of-place element from the pilot. It starts when Archie defends Jughead from Reggie Butler, Riverdale’s resident a-hole jock. Reggie accuses Jughead of murdering Jason because he’s a weird outcast. Archie defends his former buddy and gets a black eye for his trouble. After a talk with his dad, Archie decides he’s going to do the right thing and tell Principal Weatherbee what he heard on the Fourth of July. He then apologizes to Jughead for being an ass, and the two agree to become friends again. After many burgers, of course.The pep rally begins, and we get to see Josie and the Pussycats put on a real show. They perform an updated version of “Sugar, Sugar,” which was originally written for The Archies in 1969. Riverdale may not be like any version of Archie we’ve seen before, but it’s has a wonderfully nerdy appreciation for the universe it’s based on. The pep rally is cut short when Cheryl, seeing Archie wearing her brother’s uniform, breaks down in tears and runs to the locker room. Proving to everyone that she truly isn’t the spoiled rich girl, Veronica runs after Cheryl. Betty sees Veronica give Cheryl a shoulder to cry on and says not many people would have done that. Veronica, she realizes, might actually be a good person.With all the friendships back where they should be, Betty, Veronica, Archie, and Jughead meet up at Pop’s Chock’lit Shop. Everything seems like it’s going to be OK. But this is a neo-noir show, so we know that’s not the case. The next morning, Archie goes to the principal’s office to tell all, but before he can, the principal and Sheriff run to Cheryl Blossom. She confesses in front of her class that she’s guilty. Jughead’s narration teases us, saying the autopsy revealed some strange things about Jason Blossom’s death. The one thing he does reveal is that Jason Blossom died a week after he fell into the river.Madelaine Petsch as Cheryl Blossom and KJ Apa as Archie Andrews (Photo: Dean Buscher/The CW)Cheryl’s confession definitely makes things interesting. We all suspected that she killed her brother from the beginning, but now it doesn’t look so certain. After all, she told Veronica that Jason was supposed to come back. What were they doing on the river, anyway? Also, all she said was “I’m guilty.” She didn’t say what of. Clearly, this isn’t as cut and dry as it looks.Riverdale had a rare second episode that kept the plot moving, rather than further establishing the world. The pilot did all that work already, so this week, the show was free to focus on the characters, their relationships and the mystery at hand. Riverdale appears to be navigating teen drama storylines in a smart, interesting way. It definitely helps that you can identify with most of the characters or at least see where they’re coming from. Everyone is dealing with or hiding, something. That’s what makes the show so interesting, and will definitely keep me coming back week after week. SDCC 2019: ‘Riverdale’ Cast Spills Details on Core ‘Mystery’ for Season 4Top Movies and TV Panels to Keep on Your Radar for SDCC 2019 read more
2 min read Free Webinar | Sept 5: Tips and Tools for Making Progress Toward Important Goals Facebook shareholders who held onto their stock during more than a year of disappointing performance following the company’s May 2012 IPO were finally rewarded last month. In August, the company’s stock price first reached, and then exceeded, its IPO valuation of $38 a share.At least one investor has made a tidy profit from the recent gains. Mail.ru, a Russian internet services company, announced Thursday that it had cashed out its remaining Facebook shares, reportedly netting about $525 million.Mail.ru invested about $200 million in Facebook in 2009. The company sold some of its shares in the IPO, as did Peter Thiel, Facebook’s earliest investor. It sold the remaining 14.2 million shares, about 0.6 percent of Facebook’s outstanding shares, in July and August, the company said.Facebook’s IPO was plagued by technical glitches, and its stock lost half of its value over the next few months. But it has rebounded impressively in the last year as investors became more confident in the social network’s commitment to mobile. Russian billionaire Alisher Usmanov, part-owner of Mail.ru, still retains a personal stake in Facebook of an undisclosed number of shares, according to The New York Times.At time of writing, Facebook’s stock stood at $44.37, up more than three percent in Friday trading.Related: Facebook’s Hashtags Might Not Be as Social as You Think Opinions expressed by Entrepreneur contributors are their own. September 6, 2013 Attend this free webinar and learn how you can maximize efficiency while getting the most critical things done right. Register Now »read more
Attend this free webinar and learn how you can maximize efficiency while getting the most critical things done right. Register Now » 3 min read Days after dropping the title “accelerator,” this seed fund is bringing on new partners.On Wednesday, Silicon Valley-based Tandem announced it has added Shashi Seth, who has served as an executive at tech companies including Google, Yahoo and eBay, and Daniel Hoffer, a co-founder of CouchSurfing who has also worked at TripIt and Symantec.“Together our new partners have decades of experience building global consumer-facing businesses,” Doug Renert, co-founder of Tandem, said in a statement. “Tandem backs great founders from around the globe, and now they’ll all benefit from Dan and Shashi’s insights, experience and skills in the push for product-market fit.”While at Yahoo, Seth oversaw Yahoo Search, Local, Small Business and other products. At Google, he helped develop YouTube’s ad framework and worked in product development in search. Hoffer is one of the founders of CouchSurfing, a site that connects travelers with people willing to house them. The company was founded in 2004 and currently has more than 10 million members, according to its site. Both partners have served as advisors in the startup world.Related: How Millennials Can Ease Their Financial WorriesTandem, the largest mobile-first seed fund in Silicon Valley, now has 15 full-time team members who work directly with startups. With the addition of Seth and Hoffer, Tandem today has six partners including Renert and co-founder Sunil Bhargava, who started Tandem in 2007. The company has not yet brought on any female partners. The announcement of the new partners comes days after Tandem’s announcement that the company had dropped the word “accelerator” from its title. The decision came as Tandem felt the term no longer encompassed the seed fund’s involvement and investment in its startups.”We simply felt that the typical accelerator (and its close relative, the incubator) had evolved a long way from our original investment approach,” the company said Monday in a blog post. “Tandem has always been focused on backing a limited number of talented founder teams and working with them very closely to discover product-market fit.”In January, Tandem completed its third investment fund, raising $100 million, a figure that tripled the size of its previous $33 million fund. The company says that plans to use the fund to partner with startups beyond the acceleration phase and expand its program to include companies working on the Internet of Things and connected devices. Related: The Best and Worst U.S. Cities to Launch a Business April 29, 2015 Free Webinar | Sept 5: Tips and Tools for Making Progress Toward Important Goalsread more
Google is teaming up with TV manufacturer Vizio to make casting capability from a mobile device available on Vizio TVs without the need to open up an app on the device, according to a report by Variety.According to the paper, Vizio is to launch a range of TVs with casting capabilities.Google has already added casting support to Android-based TVs, with a range of models from the likes of Sony and others unveiled at CES. However the Vizio models will enable casting without the use of any on-screen apps, according to Variety.Google merged the management of its popular Chromecast streaming media dongle with Android TV last autumn under Mario Querioz.
RTL-owned multi-channel network Broadband TV has launched a new business division that will build original games and mobile apps.Broadband TV CEO Shahrzad RafatiBBTV Interactive will create multi-platform games and apps to connect digital talent with their fans, in a move that is designed to expand revenue streams and was announced at CES in Las Vegas.“We’re placing an emphasis on building mobile games that are truly broadcastable,” said Lewis Ball, vice-president interactive, e-commerce and professional services at BroadbandTV.“We’re in a unique position as we already work with top digital talent that each have large highly engaged audiences allowing us to directly market the apps to targeted consumers.”Ball described the move as a “significant opportunity” and it is one that builds on a number of previous app developments by Broadband TV.The company made a mobile game for Spanish YouTuber Fernanfloo that was downloaded by more than 9.5 million iOS and Android users, and is due to launch its latest game, Squad Rivals, as a closed beta trial later this month.Broadband TV said it has been committed to further expanding revenue streams with its monetisation strategy now spanning ad- and subscription-supported video-on-demand, mobile apps, e-commerce, and licensing.The Vancouver-based company claims to be the third largest video property globally after Google and Facebook with 34 billion views per month and 285 million unique viewers. Its total annual viewership increased 66% from 2016 to 2017 to reach 341.4 billion.Broadband TV is 51% owned by RTL Group, however the German media giant said last year that it would not exercise its call option to acquire the remaining 49% of the company and had instead decided to explore “all strategic alternatives” for Broadband TV together with minority shareholders.read more
I see you standing here, asking for help, about once a week. You are always polite, and I respect that. I’d like to do something for you… something that would matter long-term. Giving you a few notes or coins now and then may be fine, but I’d really like to improve your situation more permanently. In other words, I’d like to give you a job. I used to hire people, and I especially liked hiring people who had been denied breaks. I did that whenever I could. If you and I could be transported back in time, I’d hire you. And I’d feel good about it, because I think having a job would do you a lot of good. That fact is, however, that I can’t hire you, and I’d like you to know why. I used to run my own contracting firm. I enjoyed the work and I liked being able to drive past a building and say, “I made that.” Having employees, however, was torture. I liked having them in some ways, of course – I liked the guys and it made me happy to see them take care of their families with paychecks that I signed. That was very gratifying. But it wasn’t enough, and there are three reasons why: #1: Making Payroll My first problem was simply cash flow. I was solely responsible for having enough money in the bank every week, and that could be nerve-wracking, especially when customers weren’t paying their bills on time. It’s not fun to think that a family won’t be able to buy groceries if you can’t collect your invoices. Still, that part didn’t cause me to give up on employees. It was hard, but so long as my employees were working, we were making money, so there was always something coming in at some point. Somehow, I was able to pull it off. #2: Being Hated Over time, some of my employees became jerks. This seemed to grow from envy and from stupid ideas about labor versus management. These guys decided that I was getting rich off of them, and demanded I pay them more – more than they deserved and more than the company could afford. And the really nasty part was this: It was always the guys I had done the most for who hated me most. And as soon as I sat down with them and explained why I couldn’t pay them more, they started stealing from me. I fired the thieves, of course, but these experiences really soured me on employees. I had not only given these guys a job, but I had legitimately felt good about helping to feed their families. In return, they hated me, called me names, and stole from me. By itself, that was almost enough to make me swear off employing people, but not quite. #3: The IRS What really drove me over the edge was dealing with the government and the IRS in particular. They were abominable. I had to file forms with every payroll, and if anything on them was wrong, they penalized me – heavily. And if I paid them a single day late, they penalized me – heavily. And if they said I did something wrong – even if I didn’t – there was no way to change their verdict. Reason and evidence simply didn’t matter. I eventually talked to a tax lawyer who explained the situation to me. He said: Forget about fighting, Paul. There is no ‘innocent until proven guilty’ in tax court. You’re automatically guilty, and you have to try to prove yourself innocent… which is very hard and very expensive. Just pay them. I know you hate that, but you have no other choice. Fighting them would ruin you. It wasn’t just the money that got me about this – it was that they were nasty, arrogant, heartless tyrants. Having the facts on my side didn’t matter. Intelligent arguments didn’t matter. Either I paid what they demanded or they would hurt me worse. In many ways, it wasn’t much different than the local gang of street thugs demanding protection money. So, that’s why I can’t hire you: Having employees locked me into a single role in life, that of a despised slave. When I finally realized that, I walked away. I was lucky that I had the ability to move into specialties and to thrive in difficult niches; other guys probably couldn’t have. So… What I really want you to know is this: I’d like to help you. You deserve a chance at a decent job. I’d like to be the guy who gave it to you, but the system demands that I must live as a slave in order to do so. And I won’t do that. I very much wish that things were different, and I feel sorry every time I drive by that I can’t hire you. But I would never ask anyone to live as a slave, and I won’t live that way myself. I wish you well, and if life in these parts should ever pull back from the present reign of oppression, I hope to run into you. And on that day, I hope to either hire you or do business with you. We would both have much to gain from it. Paul Rosenberg FreemansPerspective.comread more
There’s new evidence that mild pulses of electricity can relieve depression — if they reach the right target in the brain.A study of 25 people with epilepsy found that those who had symptoms of depression felt better almost immediately when doctors electrically stimulated an area of the brain just above the eyes, a team reported Thursday in the journal Current Biology. These people were in the hospital awaiting surgery and had wires inserted into their brains to help doctors locate the source of their seizures.Several of the patients talked about the change they felt when the stimulation of the lateral orbitofrontal cortex began, says Kristin Sellers, an author of the paper and a postdoctoral researcher at the University of California, San Francisco. One person’s response was: “Wow, I feel a lot better. … What did you guys do?” The stimulation only lasted a few minutes. After it stopped, the effect on mood quickly faded. To be sure that the effect was real, the researchers also pretended to stimulate the lateral OFC in the same patients without actually running current through the tiny wires implanted in their brains. In those sham treatments, there was no discernible change.The results add to the evidence that patients with depression can be helped with an approach known as deep brain stimulation.DBS is an approved treatment for tremors, including those associated with Parkinson’s disease. But results with depression have been less consistent, and DBS isn’t approved for this purpose by the Food and Drug Administration.The latest study represents “another piece in a very complicated puzzle, a very important piece,” says Dr. Helen Mayberg, a pioneer in the use of DBS to treat depression. The study also offers strong evidence that stimulating the OFC can temporarily improve the mood of a person who is feeling depressed, says Mayberg, who directs the Center for Advanced Circuit Therapeutics, which is part of the Mount Sinai Health System in New York. But it’s unclear whether the stimulation can produce long-lasting changes, she says. Also, the study couldn’t answer a critical question because it only looked at people who were reporting transient symptoms of depression. “What happens if you did this in people who actually have failed every kind of treatment for a major depressive episode and are chronically and intractably ill,” Mayberg says.Meanwhile, her own team has been able to help about 80 percent of those patients by stimulating a different area of the brain — one that happens to share many connections with the OFC. The latest study offers “more evidence that [DBS] is something that is real and will work for depression,” says Al Fenoy, an associate professor of neurosurgery at the University of Texas Health Science Center at Houston.Fenoy is part of a team that has had success treating depression by stimulating yet another brain area that shares connections with the OFC. “We’re all (working) along a very similar pathway,” he says. “One of the common denominators might be this orbitofrontal area.”But it’s also possible that different types of depression will require different targets, Fenoy says.All of the research on brain stimulation reflects a move away from the long-held view that depression is caused by a chemical imbalance in the brain. “A more sort of modern conception is thinking of depression as a circuit dysfunction, meaning that there’s something about the way cells in the brain are talking to each other that is not quite right,” says Dr. Vikram Rao, an author of the new study and an assistant professor of clinical neurology at UCSF.So researchers have been trying to identify faulty circuits and make them work better using electrical pulses. The challenge has been to find areas that have a really good connection to the malfunctioning circuit”The way that I like to think about it is we’re trying to get onto a highway and there’s a lot of different on-ramps,” Sellers says.The UCSF team took a novel approach to this task by studying patients with epilepsy who were awaiting surgery. That meant they already had wires inserted into their brains to help doctors locate the source of their seizures.In a previous, related study, UCSF researchers had used a different group of epilepsy patients to identify circuits in the brain that indicated whether people were happy or sad. This time, they were able to use these wires to not only monitor various brain circuits involved in mood but also electrically stimulate some of those areas.The researchers were able to use the technique in many different areas in the brain. And Sellers says they got an immediate response when they stimulated the OFC. “What we found was that consistently, stimulation in the lateral OFC was improving mood in symptomatic patients,” Sellers says. What’s more, more powerful stimulation produced a more dramatic improvement in mood, she says. There were no issues with side effects, including mania, which has been seen in some previous experiments with brain stimulation.That’s probably because the OFC offers a really good on-ramp to brain networks involved in depression, Rao says. “It does seem to be a crossroads for connecting many different brain regions that had been implicated in regulating our mood.”And Rao says the results suggest that stimulation of this area is improving the function of a faulty circuit, rather than just making everyone happier.”Only the people who had symptoms [of depression] to start with improved their mood, which suggests that perhaps the effect of what we’re doing is to normalize activity that starts off abnormal,” Rao says. Copyright 2018 NPR. To see more, visit https://www.npr.org.read more
By Daisy Salas Peña, Regional Director of Witnessing and EducationOn March 22, we held a talk on True Parents for the students of “neo-Christianity”, in the course of “Religion and Politics” at the National University of Costa Rica. We had 23 students who were invited by their teacher, who is an Ambassador for Peace.We also invited the president of CARP Costa Rica to be there with us at event. During had a video presentation about True Father’s Life course and a video presentation about the national and international work of the CARP, giving a brief explanation of its contents, emphasizing on the inter-religious dialog and harmony, the family base and the practice of true love to achieve world peace. At the end of the talk the students enthusiastically applauded our presentation.Finally, we had a Q & A session which exceeded our expectations. Here are some of the questions from the participants:Rev. Moon is called “True Father of Heaven on Earth and Humanity. Does that mean you’re above the Pope?Do you have contact with the Pope?Do uou think there is al life after death?Do you have sacred books, for example, like the Bible? What practices do you do within your church? On what basis, based on what holy book?What is the role of Jesus for you? Do you believe that He is Christ?How do they practice inter-religiousness?What is the role of women in their movement? Is that in almost all religions women are relegated to the background, what is the role for you?What do you say about the rights claimed by the LGBT?If we want to know more about you where we can contact you? All the questions were answered in an atmosphere of great openness, harmony. The course’s teacher, Dr. Oscar Alvarez, explained to the students that he knew our movement, and he has often been invited many events, and so he knows about our inter-religious dialog as a means to achieve world peace which is true in action.During this talk we felt the presence of God, trying to educate this special group of young people, who were curious about life and everything that shines. And as a reasult we were filled with joy and happiness.read more
Football’s Premier League has been branded dishonest by the equality watchdog’s disability commissioner, over its attitude to access and inclusion.Lord [Chris] Holmes told MPs that there had not been “anything like an inclusive culture” in the Premier League and in Premier League clubs, which was “a great shame when it is our only national game”.He said the Premier League “needed a completely different mind-set” and pointed to the “pages and pages” devoted to broadcast arrangements in the Premier League rule book, compared with “just one line” on access.He said that changes required for television broadcasters, when new technology was introduced, were carried out “within weeks” rather than the “decades” it has taken to make access improvements.Lord Holmes, disability commissioner for the Equality and Human Rights Commission and himself a retired Paralympian, was giving evidence to the culture, media and sport select committee as part of its inquiry into access to sports stadiums for disabled people.He contrasted the Premier League’s attitude to that of Premiership rugby union and county cricket, which had both worked closely with the watchdog to improve access and inclusion.Asked by Tory MP Nigel Huddleston what he saw in those sports that was different to football’s Premier League, he said they were “collaborative, open, honest, prepared to share”.He then added, in response to a follow-up question from Huddleston, that it would be “delightful” in the future to be able to use the same words to describe the Premier League.Lord Holmes said that some clubs had done “as good as nothing” for more than 20 years to improve access.And he warned that the commission could take legal action under the Equality Act against individual clubs, and even against the Premier League itself, depending on the progress demonstrated in the next few months.He said: “I don’t think we have an inclusive culture. We don’t even have a culture of compliance from Premier League clubs and the Premier League.”The Premier League’s executive director, Bill Bush, had earlier told the committee that he could not yet name the clubs that were set to break their promise that they would meet guidelines on access laid down 13 years ago in the Accessible Stadia Guide.The Premier League said last year that all of its clubs had promised to meet the guidelines by August 2017, but Lord Holmes told the committee that probably more than a third of the clubs would fail to meet that pledge.Bush said he was not “hiding” the names of the clubs, but that it would not have been fair to name them at this stage because the Premier League had so far only carried out a “dipstick test” of their accessibility, which was not “definitive”.He said the Premier League would publish a club-by-club account of progress in January.Lord Holmes said that this refusal to release the names of individual clubs until January was “not entirely helpful”.He also pointed to a new mobile phone app that has been launched for football fans by the Premier League, even though it was not accessible.He said: “It clearly demonstrates that if that thinking is going on, there is no sense of an inclusive culture and there’s no sense of embracing the positive opportunity that exists here.”Lord Holmes praised smaller clubs like Wrexham and Tranmere Rovers, both in the fifth tier of English and Welsh football, and both of which have improved access despite their grounds being more than 100 years old.Bush claimed that Premier League clubs took the issue of access “very, very seriously” and none of them had ever said they could not afford to carry out access improvements.He claimed that any delays were due to other factors, such as the “disruption” caused by the major building work necessary to put in lifts and viewing platforms.read more
Learn how to successfully navigate family business dynamics and build businesses that excel. Airbnb Free Webinar | July 31: Secrets to Running a Successful Family Business News reporter Sweden Lists Itself on Airbnb for Free –shares Image credit: Airbnb via PC Mag Forget about a tiny, expensive Manhattan studio apartment: Why not reserve an entire rustic forest on Airbnb for your next camping trip? Or maybe your own private island? Perhaps you’d like to pitch a tent on a secluded beach with huge limestone columns jutting out of it?As long as you’re willing to make Sweden your destination, you can find all of that and more on Airbnb starting on Tuesday, and best of all, it’s free. The listings are actually a marketing gimmick devised by Sweden’s tourism agency to highlight the country’s “freedom to roam laws,” which allow anyone to access and camp on public lands for free, according to the country’s Airbnb profile. “Allemansrätten — or the freedom to roam — is a principle protected by Swedish law that gives all people the right to be free in Swedish nature,” the profile explains. “In other words, Swedish nature isn’t just a piece of land with trees and lakes and cliffs — it’s a home with all the necessities and amenities that any great home should have.”You can’t actually book any of the listings — each one simply includes a “Visit Sweden” link that takes you to the tourism agency’s website instead of a booking button. You also aren’t guaranteed to have the spot you select all to yourself, but considering that Sweden is among the least densely-populated countries in Europe, your odds are pretty good.The Swedish public lands listing is a much-needed bright spot for Airbnb. Critics claim the company strains the supply of affordable housing in major cities, and municipal governments worldwide have passed legislation that restricts the types of listings on the site. Those laws have resulted in years of litigation, especially in the U.S.Perhaps to counteract some of the negative attention, Airbnb appears to have agreed to the Swedish campaign as a goodwill gesture: Fast Company reports that neither the tourism agency nor Airbnb is getting paid. Register Now » Next Article May 24, 2017 This story originally appeared on PCMag Tom Brant 2 min read The marketing gimmick is designed to draw attention to the ‘freedom to roam’ law that allows anyone to visit Swedish public lands for free. Add to Queueread more
Next Article Opinions expressed by Entrepreneur contributors are their own. Learn how to successfully navigate family business dynamics and build businesses that excel. June 5, 2013 Add to Queue –shares Image credit: qz.com Technology Bloomberg L.P. announced today the creation of a $75 million venture capital fund called Bloomberg Beta. It says it will be run strictly for financial return rather than as a means of bringing new products and services to Bloomberg.The fund’s focus, says Roy Bahat, the head of Bloomberg Beta, is on “the next horizon for Bloomberg” in areas such as data technology, media distribution and human-computer interactions. As startups continue to disrupt established markets, many large companies are creating investment arms and incubator programs to pursue innovation.Bloomberg quietly established the fund in January, with headquarters in San Francisco, and it has already made investments in a handful of startups. Among them are cloud-computing provider Nodejitsu and programming-tutorial site Codeacademy.Bloomberg Beta exists as a separate legal entity from its parent company. Bahat says this structure will prevent ethical breaches such as preferential coverage of the startups in its portfolio by reporters in Bloomberg’s news division.Ian Finley, a vice president of research at Gartner, a technology research firm, disagrees. “The legal entity thing doesn’t actually change the picture,” he says. A “side benefit” of Bloomberg Beta may be that it can provide Bloomberg News and Businessweek reporters with “some visibility into reporting areas that their competitors might not have,” says Finley. Bloomberg came under fire last month over news that its reporters routinely spied on the activity of people who were using the company’s Bloomberg Terminals, a computer system used widely in the financial industry.Finley doesn’t doubt that Bloomberg journalists are forbidden from showing favoritism to startups in which Bloomberg Beta actually invests. But he says that won’t necessarily stop the venture capitalists from passing tips to reporters about other startups they have examined. “A typical VC firm of $75 million is not going to make that many investments, but they will review thousands of startups a year,” he says. “So there may be a huge amount of value there, with a very low chance for ethics problems.”But Bahat says his firm won’t provide inside information to the parent company’s news division. “The way that I’ll work with Bloomberg journalists is exactly the same way that I would work with journalists anywhere else,” he says. “I will protect the confidentiality of the companies that we invest in, and of the companies that we don’t invest in.”For a company with a current market capitalization of $1.25 billion, $75 million may seem like a small bank account for a venture fund. But Bahat says it’s “just the right amount of money” for working with early-stage companies. “A fund of this size actually enables you to do a lot,” he says. “We’ll be writing checks at a range of different sizes.”Bloomberg is not the only big media company to cultivate startups. The New York Times Co. also invests in digital startups. What’s more, the Times Co. opened an incubator earlier this year for early-stage media companies. Its inaugural class of three is halfway through the four-month program.”The Times has some of the smartest people in the industry, working on some of the same problems that we are,” says Andrew Whalen, co-founder of Delve, one of the timeSpace startups. Delve is a social news reader and recommendation engine designed to keep organizations on top of crucial news in their industry. “Having access to the knowledge inside this company has been pretty incredible.”Related: The New York Times Gets Into the Incubator GameWhalen calls his tenure so far at timeSpace a mutual learning experience, in which he and his seven coworkers met with “a good cross-section of teams at the Times, everyone from design to product to tech to the newsroom.” Times staffers have provided crucial insight and feedback as Delve redesigns its product, Whalen says.Whalen would not confirm whether or not the Times Co. is interested in investing in Delve. But he did say his eight-person startup will be launching a private beta with pilot companies this summer, and is planning to do a “broader public push” in the fall, at which time the company will seek Series A financing.Bloomberg Beta and other recent efforts by large media companies to cultivate startups have a predecessor in IDG Ventures, the venture-capital arm of International Data Group, the American company that owns the PCWorld and Macworld media properties. The company launched IDG Ventures in 1996.Why is now the right time for a Bloomberg venture-capital fund? Bahat cites the falling cost of starting a company, which gives rise to exciting investment opportunities for large companies. “Sometimes the best inventions come from outside your walls, and you have to embrace that,” Bahat says. Free Webinar | July 31: Secrets to Running a Successful Family Business Brian Patrick Eha 5 min read Bloomberg Opens $75 Million Venture Capital Fund Register Now »read more
1.Knowledge discovery and hypothesis generation 2.Target identification 3.Compound generation 4.Virtual screening 5.ADME/Tox 6.Predicting the outcomes of clinical trials and clinical trials enrollment 7.Personalized medicine 8.Real-world evidence analysis and actuarial pharmacology Source:https://insilico.com/ Related StoriesAdvances in artificial intelligence could shed light on aging processNew natural product fractions library to advance drug discovery effortsResearchers report new way for creating tracers used with medical imagingThe advent of artificial intelligence in the pharmaceutical industry is expected to enable the countries that did not previously engage in early-stage drug discovery and innovative medicine to leapfrog years of pharma R&D and contribute to the global push for better health. With 1.4 billion people and the government push for innovative medicines, China is expected to become the major force in the pharmaceutical industry. The authors hope that trade wars do not impact this important field. Cancer, Alzheimer’s and other diseases do not discriminate by the nation. Until there is a clear set of cures, a trade war in biotechnology R&D is equivalent to a war on all people. Advances in biomedicine require massive international collaborations, diversity, and data sharing initiatives.”We are very happy to partner with the leading scientist in China and globally, Dr. Jianfeng Pei of the Peking University on this research topic and welcome scientists from all over the world to collaborate and contribute to it”, said Alex Zhavoronkov, Ph.D., Founder, and CEO of Insilico Medicine, Inc.The Research Topic covers new AI algorithms and (or) applications in a wide range of areas such as drug target identification, systems biology, pharmacogenomics, network pharmacology, chemical property prediction, synthesis planning, molecular design and generation, protein-ligand interaction, drug-target interaction network, drug-related knowledge graphs, big data analysis for drug information, and image recognition. This Research Topic will highlight the most recent advances and perspectives on all kinds of artificial intelligence technologies used in drug design.In this Research Topic, the authors welcome Perspective and Policy papers proposing the paths for the development of innovative medicines using AI and accelerating pharma R&D in the developed and developing countries. Reviewed by James Ives, M.Psych. (Editor)Mar 19 2019The advances in Artificial intelligence (AI) have successfully propagated into the many areas such as computer vision, speech recognition, and natural language processing. AI is now rapidly propagating into the areas requiring substantial domain expertise such as biology, chemistry promising to speed up, improving the success rates, and lower the cost of drug discovery and drug development.The laboratories of Jianfeng Pei at Peking University and Alex Zhavoronkov at Insilico Medicine partner with Frontiers in Pharmacology, a leading open science platform on the research topic “AI for drug discovery and development”. This Research Topic will highlight the most recent advances and perspectives of all kinds of artificial intelligence technologies used to accelerate and improve pharmaceutical R&D.”Artificial intelligence is rapidly propagating into life sciences resulting in a wave of academic publications in the field of AI-powered drug discovery, a plethora of startups developing new strategies and pursuing innovative business models to transform pharmaceutical research and development. The pharmaceutical industry is also strengthening its internal capabilities in this area by centralizing the previously segregated data sources, hiring data scientists and investing in infrastructure,” said Jianfeng Pei, Ph.D., Peking University, Beijing.”The integration of machine learning with ever-more extensive biological data-sets promises to accelerate advancement in the field of human health in an unprecedented manner, not least to assist in tackling the ‘failure to fail’ in current drug development pipelines, previously highlighted by our Translational Pharmacology section Chief Editor Prof Alastair Stewart. We in Frontiers in Pharmacology are excited to partner with Dr. Zhavoronkov and Dr. Pei, to develop a broad-scope, open-access article collection aiming to reflect and catalyze leading-edge developments in this field globally,” said Brian Boyle, Journal Development Manager, Frontiers in Pharmacology Journal.The applications of AI in drug discovery are very broad and can be classified into several areas:read more
New cabinet ministers to be sworn in at 3 pm Saturday: Goa CM Pramod SawantGoa Chief Minister Pramod Sawant refused to name the MLAs who would be inducted but said all the four would be from the Bharatiya Janata Party, with three of them from the legislators who joined the party on Wednesday.advertisement Press Trust of India PanajiJuly 13, 2019UPDATED: July 13, 2019 04:58 IST Goa Chief Minister Pramod Sawant said the swearing-in ceremony would be held at 3 pm Saturday. (Photo: PTI)Goa Chief Minister Pramod Sawant said late on Friday night that he would reshuffle the cabinet on Saturday replacing four ministers and the swearing-in ceremony would be held at 3 pm.Ten Congress MLAs had on Wednesday joined the Bharatiya Janata Party (BJP) increasing the strength of the party to 27 on the floor of the House.Pramod Sawant said the three members from a coalition partner, Goa Forward Party, and an Independent MLA Rohan Khaunte would be dropped from the cabinet.Pramod Sawant refused to name the MLAs who would be inducted but said all the four would be from the BJP, with three of them from the legislators who joined the party on Wednesday.Speculations are rife that former leader of opposition Chandrakant Kavlekar, Philip Nery Rodrigues and Atanasio Monserratte would be inducted in the cabinet along with Deputy Speaker Michael Lobo.Pramod Sawant said the swearing-in ceremony would be held at 3 pm Saturday.This would the second cabinet reshuffle by Pramod Sawant since he took over as the chief minister three months ago. In his first cabinet reshuffle, Sawant had inducted MGP’s breakaway MLA Deepak Pauskar after dropping then deputy chief minister Sudin Dhavalikar.Asked why allies are being dropped from the cabinet, the chief minister said the decision has been taken as per directives of the central leadership.”I don’t want to go into details. We have taken this decision to give good governance to the people,” he said.Sawant has the support by three MLAs from the Goa Forward Party and an Independent.Goa Forward Party (GFP) chief and Deputy Chief Minister Vijai Sardesai had during the day said they are hoping for an amicable solution to the crisis.”The GFP is a part of the NDA and had joined the BJP-led government after talks with the saffron party’s national leadership,” Sardesai said, adding, “The present state BJP leaders were not part of the discussions then. As such, we will take appropriate steps only after talking to NDA leadership at the Centre.””We have not yet received any official communication from the BJP leaders. On the contrary, we have received indications that the matter will be sorted out amicably,” he said.Ten of the 15 Congress MLAs, led by the leader of Opposition, Chandrakant Kavlekar, switched sides and joined the Bharatiya Janata Party (BJP) on Wednesday.While the 10 MLAs and Lobo returned from Delhi, Sawant stayed back to attend a high-level meeting on Friday evening on the issue of mining in Goa, which has come to a standstill following a February 2018 Supreme Court order.Also Read | Goa CM Pramod Sawant seeks resignation of 3 ministers, independent MLA to induct new facesAlso Watch | Leaderless Congress headed towards self-destruction?For the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byAkriti Anand Nextread more